5 things you need to know about drug interactions with cannabinoids

Antifungal medication Ketoconazole

1. Elevated CBD levels

The antibiotic clarithromycin and the antifungal medication ketoconazole both inhibit CYP3A4, the liver enzyme that breaks down CBD. Taking CBD in combination with these and other drugs can raise CBD levels (ketoconazole was shown to nearly double CBD levels).

This increases the likelihood of side effects such as drowsiness and digestive issues.

Read: 7 things you need to know before taking antibiotics (slideshow)


Joyce Hollman

By Joyce Hollman

Joyce Hollman is a writer based in Kennebunk, Maine, specializing in the medical/healthcare and natural/alternative health space. Health challenges of her own led Joyce on a journey to discover ways to feel better through organic living, utilizing natural health strategies. Now, practicing yoga and meditation, and working towards living in a chemical-free home, her experiences make her the perfect conduit to help others live and feel better naturally.