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5 things you need to know about drug interactions with cannabinoids
4. Combined effects of cannabinoids and other medications
This is a case of one plus one equaling three. The additive effects of cannabinoids and certain other medications can cause unexpected side effects.
For example, oxymetazoline, found in over-the-counter decongestant nasal spray Afrin, and pseudoephedrine, found in the cold medicine Sudafed, when combined with cannabinoids can cause tachycardia (rapid heartbeat) and hypertension.