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Healthy at 100, could this be the secret?
I think we’ve moved beyond associating “anti-aging” with stopping the visible signs of aging — like wrinkles, sagging skin, age spots and such.
Anti-aging is now an area of research that goes much deeper than the skin’s surface — and that’s what really got my attention about indoles…
Indoles may hold the key to improving the way we age as opposed to simply extending how long we live.
After all, who wants to live, say, to 100 — if you are frail, sick and incapable of enjoying those additional years of life?
That’s what makes indoles so amazing.
But the best part? You don’t have to wait for someone to make an anti-aging pill to get yours…
“Manufacturing” indoles for better aging
The inhabitants of your gut, your microbiota — a community of (hopefully) diverse bacteria that live together in your gut — are key to how well everything goes with the rest of your body.
For example, obese and overweight people tend to have less diverse bacteria in their guts. This is believed to directly affect metabolic processes, like how the body uses, burns and stores energy.
A diverse microbiome has a healthy balance of good and bad bacteria. That lets it do great things for your body with what you put in it… Especially things like indoles.
Indoles are produced when your gut bacteria break down tryptophan, an amino acid. But indole and its naturally occurring chemical relatives also show up in vegetables, including Diindolylmethane, or DIM for short, a phytonutrient found in cruciferous vegetables such as broccoli, cabbage, bok choy, and cauliflower.
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Previous research has found that indoles make worms more resistant to infection and other stressors. But in a series of very recent studies at Emory University School of Medicine, indoles were found to help worms, flies, and mice not only live longer but also live better…
This is what they found in the test specimens fed bacteria that produced indoles:
- Older worms experienced increased mobility and resistance to heat stress.
- The reproductive span of older worms (typically 5 days) more than doubled.
- In very old mice, indole helped maintain their weight, mobility and activity levels. In young mice, it extended survival after radiation exposure.
In other words, indoles helped aging animals maintain vitality. And the effects were strong…
The researchers analyzed the pattern of gene activity affected by indoles and found they were distinct from other genes previously linked to longevity…
According to the study’s senior author, Daniel Kalman, Ph.D., “It’s like the Picture of Dorian Gray, in terms of the genes involved. Indoles make old animals look more like the young ones.”
Can humans benefit as much?
If you’re skeptical about whether indoles can help you live longer and better, like worms, there are a few good reasons worms are helpful in human research…
For starters, C. elegans, the nematode worm typically used in research, has a similar number of genes to humans — and many of its genes have functional counterparts in humans, which makes it a good model. Also, many of the molecular signals controlling its development are also found in more complex organisms, like us humans.
That’s about where the similarities end, except that all living things age. We need human studies before we can be sure indoles have the same impact on people.
Creating a fountain of youth in your gut
For whatever reason, as you age, the diversity of your gut microbiome changes. The spectrum of bacteria narrows — and that, in turn, reduces its positive impact on your entire body.
Building up and balancing a full-spectrum bacterial community can promote a diverse microbiome. There are a few ways to do this, but I believe adding fiber to your diet is the best way.
Fiber, after all, is considered an anti-aging nutrient. People with the highest intake have nearly an 80 percent higher chance of living a longer, healthier life than those who consume less.
Adding a good daily probiotic will also hel,p as they’ve been shown to help melt fat, fight disease and keep your body younger, as a result of beefing up your microbiome.
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Some foods support indole-producing bacteria, and they’re also the ones we’ve seen referenced time and again as health-promoting foods. Is that a coincidence?
They include:
- Broccoli
- Brussels sprouts
- Cabbage
- Kale
- Garlic
- Horseradish
- Piperine black pepper
- Onions
Indole may be an up-and-coming key anti-aging tool that we can’t help but take advantage of… and no one makes that point better than Dr. Kalman…
“Indole is such an ancient messenger,” Kalman says. “It’s how plants steer their growth, how bacteria talk to each other, and it is how plants and bacteria talk with us and ensure proper homeostasis with our immune system. It is perhaps not so surprising that these molecules help maintain our vitality.”
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Source:
By Margaret Cantwell
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