Healthy at 100, could this be the secret?

I think we’ve moved beyond associating “anti-aging” with stopping the visible signs of aging — like wrinkles, sagging skin, age spots and such.

Anti-aging is now an area of research that goes much deeper than the skin’s surface — and that’s what really got my attention about indoles…

Indoles may hold the key to improving the way we age as opposed to simply extending how long we live.

After all, who wants to live, say, to 100 — if you are frail, sick and incapable of enjoying those additional years of life?

That’s what makes indoles so amazing.

But the best part? You don’t have to wait for someone to make an anti-aging pill to get yours…

“Manufacturing” indoles for better aging

The inhabitants of your gut, your microbiota —  a community of (hopefully) diverse bacteria that live together in your gut — are key to how well everything goes with the rest of your body.

For example, obese and overweight people tend to have less diverse bacteria in their guts. This is believed to have a direct effect on metabolic processes, like how the body uses, burns and stores energy.

A diverse microbiome has a healthy balance of good and bad bacteria. That makes it able to do great things for your body with what you put into your body… especially things like indoles.

Indoles are produced when your gut bacteria break down tryptophan, an amino acid. But indole and its naturally occurring chemical relatives can be found in vegetables too, like Di-Indole Methane (DIM) — a phytonutrient is found in cruciferous vegetables, such as broccoli, cabbage, bok choy, and cauliflower.

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At middle age, you start feeling changes in your body you may chalk up to aging: energy levels hit rock bottom, weight soars, muscles become soft, skin becomes wrinkled and slack and desire tanks. You may feel past your prime — but science says that’s wrong! MORE⟩⟩


In previous research, indoles have been found to make worms more resistant to infection and other stressors. But in a series of very recent studies at Emory University School of Medicine, indoles were found to also help worms, flies and mice not only live longer, but live better…

This is what they found in the test specimens fed bacteria that produced indoles:

  • Older worms experienced increased mobility and resistance to heat stress.
  • The reproductive span of older worms (typically 5 days) more than doubled.
  • In very old mice, indole helped maintain their weight, mobility and activity levels. And in young mice, it extended their survival after exposure to radiation.

In other words, indoles helped aging animals maintain vitality. And the effects were deep…

The researchers analyzed the pattern of gene activity affected by indoles and found they were distinct from other genes previously linked to longevity…

According to the study’s senior author, Daniel Kalman, Ph.D., “It’s like the Picture of Dorian Gray, in terms of the genes involved. Indoles make old animals look more like the young ones.”

Can humans benefit as much?

In case you’re skeptical about whether indoles can help you live longer better, like the worms, there are a few good reasons why worms are helpful in human research…

For starters, C. elegans, the nematode worm typically used in research, has a similar number of genes as humans — and many of its genes have functional counterparts in humans, which makes it a good model. Also many of the molecular signals controlling its development are also found in more complex organisms, like us humans.

That’s about where the similarities end, except for that fact that all living things age — and it looks quite promising that helping your body produce indoles can have a real effect on how you experience this inevitable process.

Creating a fountain of youth in your gut

For whatever reason, one of the things that happens as you age, is that the diversity of your gut microbiome changes. The spectrum of bacteria narrows — and that narrows its positive impact on your entire body.

To use indoles to improve your vitality as you age, you’ve got to start with your gut… building up and balancing a full-spectrum bacterial community. There are a few ways to do this, but I believe adding fiber to your diet is the best way.

Fiber, after all, is considered an anti-aging nutrient. People with the greatest intake have close to an 80 percent higher chance of living a longer, healthier life than those who consume less.

Adding a good daily probiotic will also help as they’ve been shown to help melt fat, fight disease and keep your body younger, as a result of beefing up your microbiome.

The next step would be to eat foods that your gut bacteria will digest to produce indoles…

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You’ll notice that this list contains foods you’ve seen time and again referenced as healing, disease-fighting foods. That’s no coincidence. Make these a regular part of your antiaging, disease-fighting diet:

  • Broccoli
  • Brussels sprouts
  • Cabbage
  • Kale
  • Garlic
  • Horseradish
  • Piperine black pepper
  • Onions

Indole appears to be a key antiaging tool that we can’t help but take advantage of… and perhaps we’ve been meant to since the beginning of time. No one makes that point better than Dr. Kalman…

“Indole is such an ancient messenger,” Kalman says. “It’s how plants steer their growth, how bacteria talk to each other, and it is how plants and bacteria talk with us and ensure proper homeostasis with our immune system. It is perhaps not so surprising that these molecules help maintain our vitality.”

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  1. Chemicals from gut bacteria maintain vitality in aging animals: Indoles help worms/flies/mice live stronger for longer.” — Emory Health Sciences
Margaret Cantwell

By Margaret Cantwell

Margaret Cantwell began her paleo diet in 2010 in an effort to lose weight. Since then, the diet has been instrumental in helping her overcome a number of other health problems. Thanks to the benefits she has enjoyed from her paleo diet and lifestyle, she dedicates her time as Editor of Easy Health Digest™, researching and writing about a broad range of health and wellness topics, including diet, exercise, nutrition and supplementation, so that readers can also be empowered to experience their best health possible.