Two plant compounds leading the fight against colon cancer

Colon cancer is the third most common cancer worldwide, and statistics put overall survival rates below 50 percent.

Metastasis is a significant concern in colon cancer, as the spread of cancer can be fatal. Up to 20 percent of colon cancer patients show at least one metastatic site at the time of diagnosis, commonly the liver and lungs.

When we look at these numbers, together with the statistics on outcomes from conventional therapies, we can see an urgent need for integrative approaches to stop the formation and spread of this pervasive cancer.

Research shows plant-based compounds may be our most powerful tool…

Plant-based prevention

A recent study shows certain vegetables can help…

Published August 14, 2018, in the journal, Immunity, this preclinical study demonstrates the mechanisms by which vegetables such as kale, broccoli and others in the cruciferous family protect against colon cancer.

These vegetables are high in a health-supportive compound called indole-3-carbinole (I3C). The study showed, for the first time, that I3C activates a specific protein called aryl hydrocarbon receptor (AhR). This protein acts as an environmental sensor in the digestive tract, communicating signals to immune and epithelial cells in the gut lining, to protect from inflammatory responses and maintain barrier integrity.

Why does that matter? These effects are shown to reduce inflammation and related colon cancer development.

This study adds to the important body of data highlighting the value of specific plant-based compounds in protecting against colon cancer…

Inhibiting the spread of cancer

Another important new study shows Modified Citrus Pectin (MCP) offers benefits in blocking colon cell migration through inhibition of oncogenic protein, galectin-3 (Gal-3).

Published September 2018 in the American Journal of Translational Research, results showed that MCP effectively blocked migration of aggressive colon cells, through inhibition of Gal-3. Extracellular Gal-3 was shown for the first time to play a key role in promoting colon cell migration and was also shown to upregulate EGFR (epidermal growth factor receptor) in aggressive cellular behavior.

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These important new findings add to the extensive body of published, peer-reviewed data on the role of Gal-3 in cellular function and migration. They also further substantiate the fast-growing body of research on MCP and the only available Gal-3 blocker with extensive benefits in key areas of health.

What is MCP?

Also known as citrus pectin, it’s a digestible form of pectin — the gelling agent you may be familiar with if you make jams or jellies. It’s chemically extracted from the peels, seeds and pulp of citrus fruits.

Emphasizing a plant-based diet and incorporating researched nutraceutical ingredients are two important ways to support colon health, reduce inflammation and help prevent cancer formation and metastasis. Together with regular exercise and healthy stress relief, we can create a comprehensive plan to support overall health and reduce colon cancer risks significantly.

For more health and wellness information, visit www.dreliaz.org