15+ herbs, vitamins and nutrients that help fight dementia

Despite decades of research, there is no cure for Alzheimer’s dementia.

That doesn’t mean all hope is lost to avoid this devastating disease…

Many lifestyle factors have been shown to play a role in reducing risk.

Also, widely studied are the effects of herbs, vitamins and other nutrients and compounds that have some positive impact.

Current medications, at best, may slow the rate of dementia progression. So, shouldn’t we consider natural options that may do the same or better?

Let me share them with you…

Polyphenolic herbs and extracts

These antioxidant and anti-inflammatory extracts have been studied in rodents and found to be safe and effective. They are used in humans but have few clinical trials as of yet. These include extracts from green tea (EGCG), Ginkgo biloba + ginseng, blueberries (anthocyanins), grape seeds (resveratrol), curcumin, marine algae (fucoxanthin) cat’s claw, bilberry, and black currant. Here is further information on these:

  1. Cat’s claw (Uncaria tomentosa) extract contains antioxidant polyphenols and proanthocyanidins; it is a strong antioxidant and anti-inflammatory, a potent enhancer of DNA repair in primary organ cultures of human skin, and has been found to have a high binding affinity to beta-amyloid protein.
  2. Bilberry and black currant extracts contain phenolic compounds that were shown to greatly reduce brain beta-amyloid protein and improve memory in Alzheimer’s mice.
  3. Huperzine A (Huperzia serrata, an extract from moss): 200 micrograms twice daily inhibits acetylcholine esterase.  Two double-blind clinical trials in China showed it to be safe and effective for the long-term treatment of Alzheimer’s dementia. It was found to be superior to Aricept, with longer-lasting effects and fewer side effects. Reports from an estimated 100,000 people treated suggest low toxicity for this herb.  Additionally, it decreases neuronal cell death caused by toxic levels of glutamate, which makes it useful in strokes and epilepsy too.
  4. Vinpocetine: 20 mg daily. It has been well-proven to have cerebral blood-flow enhancing and neuroprotective effects without adverse events. Several studies indicate it is useful to reduce memory loss and cognitive decline.

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Amino acids

  1. Acetyl-l-carnitine: 500-1,000 mg three times daily helps reverse the disease process of Alzheimer’s dementia. For example, memory and cognitive scores in Alzheimer’s patients given 2250-3,000 mg daily of Acetyl-l-carnitine improved 2.8 times better than placebo-treated subjects over 12 weeks in one study.
  2. L-glutamine and L-tyrosine 3-5 grams daily also help prevent Alzheimer’s dementia progression.

Phosphatidylserine and Omega-3 oils

  1. Phosphatidylserine (PS): 100 mg three times daily or 300 mg daily has been repeatedly shown in studies to improve memory in aging patients with memory complaints and early cognitive decline, yet there are a few that show no significant improvement by PS supplementation. In a multi-university study, subjects who took PS achieved a 30 percent improvement in cognitive function, including learning, memory, and recalling numbers, names and faces, and another study showed that PS supplementation had a 33 percent improvement in learning and remembering written information compared to the placebo control group. PS also works synergistically with vitamin B12 supplementation.
  2. Phosphatidylcholine (lecithin): 1-2 Tbsp/day has been shown to improve cognitive function only in early stages of Alzheimer’s dementia, and there is a “therapeutic window dose” above which the beneficial effects of lecithin treatment are lost.
  3. Omega-3 oil (Krill oil and/or flaxseed oil): 1-3 Tbsp/day. Omega 3 oils (DHA, EPA) are the building blocks of nerve tissue.

Vitamins

  1. Vitamin B1 (thiamine): Thiamine is important for acetylcholine metabolism and release from the presynaptic neuron. Deficiency of thiamine has been shown to increase β-amyloid plaque accumulation in many studies. Dosing of 3 to 8 grams daily of oral thiamine had a mildly beneficial effect on Alzheimer’s in a 1993 study although a later study in 1996 found similarly good effects with a daily dose of just 100 mg thiamine for 12 weeks.
  2. Vitamins B6, B12 and folate help reduce homocysteine, a known risk factor for Alzheimer’s dementia.  Deficiency of Vitamin B12 can Alzheimer’s symptoms, and one-fourth of people aged 60 – 70 and approximately forty percent of those over age 80 are deficient in Vitamin B12, largely from poor absorption. Vitamin B12 works synergistically with phosphatidylserine supplementation.
  3. Vitamin D3: a recent meta-analysis reveals that low vitamin D levels predict poor memory and other cognitive dysfunction and vitamin D repletion in these subjects improved brain executive functions while it showed no difference with control groups. A study reported in 2013 tells us that vitamin D restores suppressed synaptic transmission when given to Alzheimer’s rats.
  4. Vitamin E (d-alpha-tocopherol with mixed tocopherols): 800 IU twice daily for up to 2 years is safe and has been reported to slow the progression of Alzheimer’s dementia, probably because it is synergistic with CoEnzyme Q10, an endogenous compound that decreases with age.

Natural compounds

  1. Coenzyme Q10: 200 mg daily. This is shown to boost brain mitochondrial activity and provide a protective effect in rodent nerve tissue, especially when taken together with vitamin E. In 2011 a study in the Journal of Alzheimer’s Disease reported that coenzyme Q10 decreased amyloid-beta pathology and improved behavioral and cognitive performance in Alzheimer’s mice (transgenic mouse model).
  2. Nicotinamide adenine dinucleotide (NADH): 10 mg/day, 30 minutes before breakfast. A small double-blind study found no evidence of progressive cognitive deterioration and significantly higher cognitive performance scores among Alzheimer’s dementia patients who took 10 mg daily for 6 months compared with those treated with a placebo.

Peak PS

It’s a mouthful, but Phosphatidylserine, or PS for short, is a nootropic that promotes brain health, memory, clarity, reasoning and comprehension. This nutrient is a key building block for the cells in your brain, that scientific literature has shown can… MORE⟩⟩

Best foods for Alzheimer’s dementia

The best foods are those with the highest complete protein, anti-oxidant activity, and mineral content and that have an anti-inflammatory effect. To give you some ideas, consider these:

  • Wild salmon (omega-3 oil)
  • Cacao powder or dark chocolate (not chocolate bars with high sugar content)
  • Matcha (Gyokuru green tea powder): EGCG (Epigallocatechin Gallate) content as high as 10 times other green teas
  • Acai berries or blueberries (strongest antioxidants)
  • Coffee beans: regular coffee consumption has been shown in several studies to reduce dementia (from fresh ground beans, without artificial creams/sweeteners)
  • Grape juice, pomegranate juice (antioxidant resveratrol)
  • Apples (the antioxidant flavonoid, quercetin)
  • Leafy green vegetables such as spinach and collard greens (phytonutrients)
  • Avocados, unsalted nuts, and seeds (vitamin E, healthy oil)
  • Goji berries (a.k.a. wolfberries) have strong antioxidant properties
  • Allum foods: garlic, onions, chives, leeks, shallots, and scallions. These contain flavonoid antioxidants thought to reduce the Alzheimer’s disease process.
  • More great foods: bananas, brewer’s yeast, broccoli, brown rice, Brussels sprouts, cantaloupe, feta cheese, chicken, collard greens, eggs, flaxseed oil, legumes, oatmeal, oranges, peanut butter, peas, potatoes (not in excess), romaine lettuce, soybeans, spinach, tuna, turkey, wheat germ, and plain yogurt.

Remember to eliminate the following foods as much as possible: Alcohol; artificial food colorings; artificial sweeteners; colas, sodas, and high-sugar drinks; corn syrup and high fructose corn syrup; frostings; hydrogenated fats; junk sugars; white bread; and nicotine.

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Sources:

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  3. Wesnes KA, Ward T, McGinty A, Petrini O. The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers. Psychopharmacology (Berl). 2000 Nov;152(4):353-61.
  4. Brewer GJ, Torricelli JR, Lindsey AL, Kunz EZ, Neuman A, Fisher DR, Joseph JA. Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem. 2010 Oct;21(10):991-8.
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  6. Peng J, Yuan JP, Wu CF, Wang JH. Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health.  Mar Drugs. 2011;9(10):1806-28.
  7. Pangestuti R, Vo TS, Ngo DH, Kim SK. Fucoxanthin Ameliorates Inflammation and Oxidative Reponses in Microglia. J Agric Food Chem. 2013 Apr 12. This study found that fucoxanthin ameliorates oxidative stress and inflammation in amyloid-β42 (Aβ42)-induced BV2 microglia cells and thereby may protect neuronal cells from neurotoxic mediators.
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  29. Alternative Treatments — Alzheimer’s Association®

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Dr. Michael Cutler

By Dr. Michael Cutler

Dr. Michael Cutler is a graduate of Tulane University School of Medicine and is a board-certified family physician with more than 20 years of experience. He serves as a medical liaison to alternative and traditional practicing physicians. His practice focuses on an integrative solution to health problems. Dr. Cutler is a sought-after speaker and lecturer on experiencing optimum health through natural medicines and founder of the original Easy Health Options™ newsletter — an advisory on natural healing therapies and nutrients. His current practice is San Diego Integrative Medicine, near San Diego, California.