What I tell my patients about statins

I may have started a company that makes food to help lower cholesterol, but that doesn’t mean I don’t prescribe statins.

In fact, I do it all the time. Because some people SHOULD be on these drugs.

However, I only prescribe medications when the indication is clear — and always with the caveat that drugs alone are an incomplete solution.

Where the guidelines lead

There are 4 main categories of patients in whom guidelines dictate that statins should be utilized:

  1. Those with known heart disease (like prior heart attack, stroke, bypass surgery, stent, etc.).
  2. Those with diabetes (who are at least 40 years of age).
  3. Those with familial hypercholesterolemia (genetically driven very high LDL, typically defined as an LDL at or above 190 mg/dL)
  4. Those with a calculated 10-year risk of experiencing heart disease that exceeds 7.5 percent.

A couple of these categories are no brainers. The data is really strong and consistent that statin medications significantly reduce the risk of heart events in patients with established heart disease and in those with diabetes regardless of starting LDL value. 

Remember, we don’t put people on drugs to make numbers look good. We put people on medications to positively impact outcomes. The LDL number is just a proxy for how much we are reducing risk.  And not all risk benefits of statins come from cholesterol reduction alone.

And although many patients come to see me because they want to avoid medications or get off of statins, if you have established heart disease, I will work hard to keep/put you on them… forever. 

In patients with diabetes, which can be reversed with lifestyle change, I always leave the door open for discontinuing the statin if the diabetes goes away.

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The impressive effects of lifestyle changes on cholesterol

LDL levels of 190 mg/dL are typically driven at least in part or in whole by genetics, but I’ve seen significant LDL drops in those with high starting numbers with lifestyle change alone. 

Just last week a patient surprised even me by dropping her LDL from 285 mg/dL to 169 mg/dL simply by adjusting her diet!  Yes, you read those numbers right.  And yes, I did mean LDL. And this didn’t take years — she accomplished this within a couple of months. 

So in patients with elevated LDL as an isolated finding, I avoid prescribing statins until we’ve tried a concerted lifestyle change for at least 3 months.  And if significant improvements occur within that time period, I keep going with lifestyle change and periodic cholesterol checks until we’ve reached a plateau — and then decide if statins are required.

That 7.5 percent risk-based category (part of the statin guidelines above) is the one I’m least excited about — and typically ignore. 

That’s because the risk calculator is in many ways flawed. It uses population data about heart disease risk and attempts to apply it to individuals.  And it’s highly weighted for age — but doesn’t consider family history. 

That means a healthy 70-year-old woman — without any risk factors for heart disease and exceptional healthy longevity in her family — would be considered a statin candidate (with normal cholesterol levels), while a 45-year-old man — who recently quit smoking, is overweight, has an LDL of 170 mg/dL and whose family history shows every male relative died at 50 from a massive heart attack — goes statin free! 

Statins: Not so cut and dry

You can see why, then, if I see someone who falls into category #4 — and a lot of people do — I really try to be thoughtful about whether or not to get out my prescription pad.  That involves considering the whole person and their health goals. 

If you’re in my office because the risk calculator says you should be, I will go over everything you can do to lower your risk from every angle — not just cholesterol.  And in some cases will check a coronary calcium scan to obtain a more individualized assessment of heart disease risk.

And, because it bears repeating, whether I prescribe statins or not, I always emphasize the importance of diet.  Food can help lower cholesterol, independently reduce heart disease risk and also help statins work better — meaning you will need lower doses to control your readings thus reducing the likelihood of statin-related side effects

Dr. Elizabeth Klodas MD, FACC

By Dr. Elizabeth Klodas MD, FACC

"Diet is a major driver of high cholesterol, but instead of changing the food, we prescribe medications. This never seemed logical to me.” Dr. Klodas has dedicated her career to preventive cardiology. Trained at Mayo Clinic and Johns Hopkins, she is the founder and Chief Medical Officer for Step One Foods. Dr. Klodas is a nationally sought out speaker and has an active role at the American College of Cardiology. Her clinical interests include prevention of heart disease and non-invasive cardiac imaging and she has published dozens of scientific articles throughout her career. Dr. Klodas has been featured on CNN Health for her mission to change how heart disease is treated. An independent study performed at leading medical institutions affirmed the ability of Step One Foods to deliver measurable and meaningful cholesterol-reduction benefits in the real world. The results of the trial were presented at the 2018 American Heart Association’s Scientific Sessions. Dr. Klodas has also authored a book for patients, "Slay the Giant: The Power of Prevention in Defeating Heart Disease," and served as founding Editor-in-Chief of the patient education effort of the American College of Cardiology. In addition to her practice and her duties at Step One Foods, she also serves as medical editor for webMD.