These supplements fight heart disease BETTER than statin drugs

In my previous article I discussed phytonutrients in food you can use to lower cardiovascular risk before you start taking a statin drug. This article discusses phytonutrients and other supplements that have great science to substantiate their use in the prevention of cardiovascular disease.

Nutrient Supplements Proven To Beat Heart Disease

If you take many of these supplements, you can expect to reduce your cardiovascular disease risk more effectively than taking a statin drug even though there are no large clinical trial data to prove this. No one has performed a “head to head” clinical trial comparing a statin drug to a combination of multiple supplements designed to beat heart disease.

Yet, you can find these supplements in your local health food store or online, and their benefits in supporting heart health are supported by the peer-reviewed scientific literature [1] [2]:

  • Vitamin K2 MK7: 100-150 mcg daily decreases C-reactive protein, increases arterial elasticity, decreases arterial plaque [3] and decreases coronary heart disease and total mortality. The seven-year prospective Rotterdam Study [4] of 4807 subjects (2004) as well as a later prospective study [5]  (2009) of 16,057 women showed significant reduction in heart attack and all-cause deaths at 22-50 mcg daily and 30-40 mcg daily, respectively.
  • Polyphenols: Resveratrol [6],  quercetin, flavonoids, red wine (6 ounces twice weekly), dealcolholyzed red wine [7], purple grape juice [8] (independent of alcohol content), red grape polyphenolic extract [9], dark chocolate [10]  [11], pomegranate juice [12]  [13]  and other plant-derived polyphenols [14] have been shown to reduce endothelial inflammation [15] and/or increase nitric oxide (a vasodilator).

Peak Cardio Platinum

Clinically-Tested Nutrients Help Arteries and Cardiovascular Health!

  • Omega 3 fatty acids (fish or fish oil): 5,000 mg daily with EPA/DHA at a ratio of  3:2 lowers endothelial inflammation. [16] [17]
  • CoEnzymeQ10: Has been shown to lower blood pressure by 17/10 mm Hg at modest doses of 60 mg twice daily in a meta-analyses [18] of 12 studies (n=362). In another study [19] this dose reduced blood pressure by 26 mm Hg systolic on average of the 55 percent who responded to treatment.
  • Green coffee bean extract: Contains chlorogenic acid, shown in a number of studies to significantly lower blood pressure. [20]  [21]  [22]  [23] [24] An average dose of 140mg daily lowered blood pressure 5.6 mmHg systolic and 3.9 mmHg diastolic.
  • Soy isoflavones: [25] [26] Because they contain diadzein and genistein, are known to lower blood pressure.
  • Lycopene extract: Lowered blood pressure by 9/7 mm Hg in a small study [27] (n=30) for 8 weeks; when added to ACE-inhibitor, calcium channel blocker or a diuretic medication, it lowered blood pressure by 10 / 5 mm Hg. [28]
  • Arginine: 6 grams daily significantly increases nitric oxide secretion, which is a powerful vasodilator with endothelial anti-inflammatory effects, [29] [30]  [31]  especially in salt-sensitive people. [32] A meta-analysis of 11 randomized, double-blind, placebo-controlled trials (total of 387 subjects) using 4 to 24 grams daily lowered pressure 5.39 mm Hg systolic and 2.66 mm Hg diastolic on average. [33]
  • Carnitine: 1 gram twice daily lowers blood pressure and lowers insulin resistance. [34] [35] The optimum dose is 3 grams twice daily for the hypertensive diabetic person.
  • Taurine: Lowers blood pressure and has cardioprotective effects [36] at the dose of 3 grams twice daily.
  • Alpha lipoic acid: Lowers blood pressure [37]; improves endothelial dysfunction [38]; reduces reactive oxygen species and oxidative stress [39] and has other cardio-protective mechanisms. [40] The optimal dose is 300-600mg twice daily.
  • Hawthorn berry: Has ACE inhibition effects (like the prescription ACE inhibitors such as Lisinopril®) and mildly reduces systemic vascular resistance. [41] [42] [43]
  • Herbal teas: Green tea extract contains epigallocatechin gallate (EGCG), which has been shown to lower blood pressure. [44] Dandelion leaf tea is a mild diuretic and, therefore, can lower blood pressure. Fresh ginger tea lowers  blood pressure. [45]  Hibiscus tea helps lower blood pressure according to a few studies. [46] [47]
  • B vitamins: Niacin (vitamin B3, aka nicotinic acid) 500-1,000 mg is a vasodilator; the extended release form lowers blood pressure and raises good cholesterol levels. [48] [49] Pyridoxine (vitamin B-6) stabilizes nitric oxide [50] (a potent vasodilator).
  • Vitamin D3: Low vitamin D3 is causally related to heart disease deaths [51]; make sure your blood levels are at 60-80 ng/ml, which usually requires taking 2,000 to 5,000 IU daily by supplementation if you are low. There is a high prevalence of vitamin D deficiency in the general population with a direct correlation to cardiovascular disease. [52]
  • D-ribose: [53] Improves angina, heart failure, arrhythmias, weakness and fatigue at 5 grams 3-4 times daily for those already diagnosed with heart disease.
  • Aged garlic (Kyolic): Clearly cardioprotective with multiple mechanisms for its benefits. [54] [55] Clinical experience shows 600 mg twice daily reduces coronary artery plaque progression in people on statins. [56] [57]


The new cardiovascular disease risk guidelines provide better information for physicians and patients than ever before, especially by asking physicians to treat obesity as a disease and to get serious about guiding patients with dietary and other lifestyle-related interventions. I have given you many safe and natural options to lower your cardiovascular risk and beat heart disease that were not covered in the new guidelines.

Editor’s note: There are numerous safe and natural ways to decrease your risk of blood clots including the 25-cent vitamin, the nutrient that acts as a natural blood thinner and the powerful herb that helps clear plaque. To discover these and more, click here for Hushed Up Natural Heart Cures and Common Misconceptions of Popular Heart Treatments!


[1] Houston, MC et al. Nonpharmacologic Treatment of Dyslipidemia. Progress in Cardiovascular Disease 2009;52:61-94

[2] Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hilpert KF, Griel AE, Etherton TD. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer.  Am J Med. 2002 Dec 30;113 Suppl 9B:71S-88S.

[3] Wallin R, Schurgers L, Wajih N. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thromb Res. 2008;122(3):411-7.

[4] Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC.

Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004 Nov;134(11):3100-5.

[5] Gast GC, de Roos NM, Sluijs I, Bots ML, Beulens JW, Geleijnse JM, Witteman JC, Grobbee DE, Peeters PH, van der Schouw YT. A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metab Cardiovasc Dis. 2009 Sep;19(7):504-10.

[6] Biala A, Tauriainen E, Siltanen A, Shi J, Merasto S, Louhelainen M, Martonen E, Finckenberg P, Muller DN, Mervaala E. Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes. Blood Press. 2010 Jun;19(3):196-205.

[7] Chiva-Blanch G, Urpi-Sarda M, Ros E, Arranz S, Valderas-Martínez P, Casas R, Sacanella E, Llorach R, Lamuela-Raventos RM, Andres-Lacueva C, Estruch R. Dealcoholized red wine decreases systolic and diastolic blood pressure and increases plasma nitric oxide: short communication. Circ Res. 2012 Sep 28;111(8):1065-8.

[8] Stein JH, Keevil JG, Wiebe DA, Aeschlimann S, Folts JD. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation. 1999 Sep 7;100(10):1050-5.

[9] Lekakis J, Rallidis LS, Andreadou I, Vamvakou G, Kazantzoglou G, Magiatis P, Skaltsounis AL, Kremastinos DT. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil. 2005 Dec;12(6):596-600.

[10] Grassi D, Lippi C, Necozione S, Desideri G, Ferri C. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr. 2005 Mar;81(3):611-4.

[11] Taubert D, Roesen R, Schömig E. Effect of cocoa and tea intake on blood pressure: a meta-analysis. Arch Intern Med. 2007 Apr 9;167(7):626-34.

[12] Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis. 2001 Sep;158(1):195-8.

[13] Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, Volkova N, Presser D, Attias J, Liker H, Hayek T. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr. 2004 Jun;23(3):423-33.

[14] Kanti Bhooshan Pandey and Syed Ibrahim Rizvi. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009 Nov-Dec; 2(5): 270–278. Online at:

[15] Layne J, Majkova Z, Smart EJ, Toborek M, Hennig B. Caveolae: a regulatory platform for nutritional modulation of inflammatory diseases. J Nutr Biochem. 2011 Sep;22(9):807-11.

[16] Alexander JW. Immunonutrition: the role of omega-3 fatty acids. Nutrition. 1998 Jul-Aug;14(7-8):627-33.

[17] Sagara M, Njelekela M, Teramoto T, Taguchi T, Mori M, Armitage L, Birt N, Birt C, Yamori Y. Effects of docosahexaenoic Acid supplementation on blood pressure, heart rate, and serum lipids in Scottish men with hypertension and hypercholesterolemia. Int J Hypertens. 2011 Mar 8;2011:809198.

[18] Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, Watts GF. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007 Apr;21(4):297-306.

[19] Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J 2001;94(11):1112-1117.

[20] Watanabe T, Arai Y, Mitsui Y, Kusaura T, Okawa W, Kajihara Y, Saito I.The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens. 2006 Jul;28(5):439-49.

[21] Ochiai R, Jokura H, Suzuki A, Tokimitsu I, Ohishi M, Komai N, Rakugi H, Ogihara T. Green coffee bean extract improves human vasoreactivity. Hypertens Res. 2004 Oct;27(10):731-7.

[22] Yamaguchi T, Chikama A, Mori K, Watanabe T, Shioya Y, Katsuragi Y, Tokimitsu I. Hydroxyhydroquinone-free coffee: a double-blind, randomized controlled dose-response study of blood pressure. Nutr Metab Cardiovasc Dis. 2008 Jul;18(6):408-14.

[23] Ochiai R, Chikama A, Kataoka K, Tokimitsu I, Maekawa Y, Ohishi M, Rakugi H, Mikami H. Effects of hydroxyhydroquinone-reduced coffee on vasoreactivity and blood pressure. Hypertens Res. 2009 Nov;32(11):969-74.

[24] Kozuma K, Tsuchiya S, Kohori J, Hase T, Tokimitsu I. Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertens Res. 2005 Sep;28(9):711-8.

[25] Helena J. Teede, Barry P. McGrath, Lakmini DeSilva, Marja Cehun, Andriana Fassoulakis, Paul J. Nestel. Isoflavones Reduce Arterial Stiffness; A Placebo-Controlled Study in Men and Postmenopausal Women. Arteriosclerosis, Thrombosis, and Vascular Biology. 2003; 23: 1066-1071. Published online at:

[26] Miguel Rivas, Ricardo P. Garay, Jesús F. Escanero, et al.  Soy Milk Lowers Blood Pressure in Men and Women with Mild to Moderate Essential Hypertension. J. Nutr. July 1, 2002 vol. 132 no. 7 1900-1902. Published online at:

[27] Engelhard YN, Gazer B, Paran E. Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: a double-blind, placebo-controlled pilot study. Am Heart J. 2006 Jan;151(1):100.

[28] Paran E, Novack V, Engelhard YN, Hazan-Halevy I. The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients. Cardiovasc Drugs Ther. 2009 Apr;23(2):145-51.

[29] Higashi Y, Oshima T, Ozono R, Watanabe M, Matsuura H, Kajiyama G.Effects of L-arginine infusion on renal hemodynamics in patients with mild essential hypertension. Hypertension. 1995 Apr;25(4 Pt 2):898-902.

[30] Higashi Y, Oshima T, Watanabe M, Matsuura H, Kajiyama G. Renal response to L-arginine in salt-sensitive patients with essential hypertension. Hypertension. 1996 Mar;27(3 Pt 2):643-8.

[31] Siani A, Pagano E, Iacone R, Iacoviello L, Scopacasa F, Strazzullo P. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens. 2000 May;13(5 Pt 1):547-51.

[32] Campese VM, Amar M, Anjali C, Medhat T, Wurgaft A. Effect of L-arginine on systemic and renal haemodynamics in salt-sensitive patients with essential hypertension. J Hum Hypertens. 1997 Aug;11(8):527-32.

[33] Dong JY, Qin LQ, Zhang Z, Zhao Y, Wang J, Arigoni F, Zhang W. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J. 2011 Dec;162(6):959-65.

[34] Ruggenenti P, Cattaneo D, Loriga G, Ledda F, Motterlini N, Gherardi G, Orisio S, Remuzzi G. Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy. Hypertension. 2009 Sep;54(3):567-74.

[35] Rajasekar P, Palanisamy N, Anuradha CV. Increase in nitric oxide and reductions in blood pressure, protein kinase C beta II and oxidative stress by L-carnitine: a study in the fructose-fed hypertensive rat. Clin Exp Hypertens. 2007 Nov;29(8):517-30.

[36] Yamori Y, Taguchi T, Hamada A, Kunimasa K, Mori H, Mori M. Taurine in health and diseases: consistent evidence from experimental and epidemiological studies. J Biomed Sci. 2010 Aug 24;17 Suppl 1:S6.

[37] Vasdev S, Ford CA, Parai S, Longerich L, Gadag V.Dietary alpha-lipoic acid supplementation lowers blood pressure in spontaneously hypertensive rats. J Hypertens. 2000 May;18(5):567-73.

[38] Li CJ, Zhang QM, Li MZ, Zhang JY, Yu P, Yu DM. Attenuation of myocardial apoptosis by alpha-lipoic acid through suppression of mitochondrial oxidative stress to reduce diabetic cardiomyopathy. Chin Med J (Engl). 2009 Nov 5;122(21):2580-6.

[39] Ghibu S, Richard C, Vergely C, Zeller M, Cottin Y, Rochette L. Antioxidant properties of an endogenous thiol: Alpha-lipoic acid, useful in the prevention of cardiovascular diseases. J Cardiovasc Pharmacol. 2009 Nov;54(5):391-8.

[40] Sudheesh NP, Ajith TA, Janardhanan KK, Krishnan CV. Palladium alpha-lipoic acid complex formulation enhances activities of Krebs cycle dehydrogenases and respiratory complexes I-IV in the heart of aged rats. Food Chem Toxicol. 2009 Aug;47(8):2124-8.

[41] Schussler M, Holzl J, Fricke U. Myocardial effects of flavonoids from Crataegus species. Arzneimittelforschung 1995 45(8):842-5.

[42] Bahorun, T. Antioxidant activities of Crataegus monogyna extracts. Planta Medica 1994 60:323-8

[43] Busse W. Standardized Crataegus extract clinical monograph. Q Rev Nat Med 1996 189-97.

[44] Yang YC, et al.The protective effect of habitual tea consumption on hypertension. Arch Intern Med. 2004 Jul 26;164(14):1534-40.

[45] Chen ZY, Peng C, Jiao R, Wong YM, Yang N, Huang Y. Anti-hypertensive nutraceuticals and functional foods. J Agric Food Chem. 2009 Jun 10;57(11):4485-99.

[46] McKay DL, Chen CY, Saltzman E, Blumberg JB. Hibiscus sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J Nutr. 2010 Feb;140(2):298-303.

[48] Bays HE, Rader DJ. Does nicotinic acid (niacin) lower blood pressure? Int J Clin Pract. 2009 January; 63(1): 151–159.  Published online at:

[49] Bays HE, Maccubbin D, Meehan AG, Kuznetsova O, Mitchel YB, Paolini JF. Blood pressure-lowering effects of extended-release niacin alone and extended-release niacin/laropiprant combination: a post hoc analysis of a 24-week, placebo-controlled trial in dyslipidemic patients. Clin Ther. 2009 Jan;31(1):115-22.

[50] Dakshinamurti K, Dakshinamurti S. Blood pressure regulation and micronutrients. Nutr Res Rev. 2001 Jun;14(1):3-44

[51] Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol. 2006 Sep;92(1):39-48.

[52] Anderson JL, May HT, Horne BD, Bair TL, Hall NL, Carlquist JF, Lappé DL, Muhlestein JB; Intermountain Heart Collaborative (IHC) Study Group. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Am J Cardiol. 2010 Oct 1;106(7):963-8.

[53] Shecterle LM, Terry KR, St Cyr JA. The patented uses of D-ribose in cardiovascular diseases. Recent Pat Cardiovasc Drug Discov. 2010 Jun;5(2):138-42.

[54] Khatua TN, Adela R, Banerjee SK. Garlic and cardioprotection: insights into the molecular mechanisms. Can J Physiol Pharmacol. 2013 Jun;91(6):448-58.

[55] Ginter E, Simko V. Garlic (Allium sativum L.) and cardiovascular diseases. Bratisl Lek Listy. 2010;111(8):452-6.

[56] Rai SK, Sharma M, Tiwari M. Inhibitory effect of novel diallyldisulfide analogs on HMG-CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target.  Life Sci. 2009 Jul 31;85(5-6):211-9.

[57] Presentation by Mark Houston, M.D. (cardiologist) at the American Academy of Anti-aging Medicine fellowship module II.


Dr. Michael Cutler

By Dr. Michael Cutler

Dr. Michael Cutler is a graduate of Tulane University School of Medicine and is a board-certified family physician with more than 20 years of experience. He serves as a medical liaison to alternative and traditional practicing physicians. His practice focuses on an integrative solution to health problems. Dr. Cutler is a sought-after speaker and lecturer on experiencing optimum health through natural medicines and founder of the original Easy Health Options™ newsletter — an advisory on natural healing therapies and nutrients. His current practice is San Diego Integrative Medicine, near San Diego, California.