Resistant blood pressure linked to surprising cause of brain inflammation

My mother had high blood pressure, and I’ve inherited it from her.

Naturally, I’m conscientious about salt in my diet. I don’t even own a saltshaker! And I take a daily pill that keeps my blood pressure under control.

I’m one of the lucky ones. For many people with hypertension, medication is not effective. And until now, the reason for this was a mystery.

Science has always believed that hypertension begins in the kidneys, and medications are based on this assumption.

However, new brain imaging techniques are now proving that we’ve got it all wrong…

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Too much salt may inflame the brain

It’s commonly thought that hypertension begins in the kidneys, which filter blood to regulate the amount of sodium and water in the body.

When blood pressure rises, the kidneys excrete more sodium and water to reduce blood volume and lower pressure.

High blood pressure also damages the delicate blood vessels in the kidneys, triggering the release of the hormone renin, which in turn causes hypertension. Thus, a vicious cycle occurs.

But now we’re learning that when high blood pressure is resistant to treatment, it may be that the drugs are aimed at the wrong organ and the wrong hormone.

Researchers at McGill University in Montreal have discovered that cases of drug-resistant hypertension may originate not in the kidneys but in the brain.

They gave rats a solution of water and two percent salt. This is comparable to a daily diet high in fast food and processed foods like bacon.

The high-salt diet activated immune cells in a specific brain region, leading to inflammation and a surge in another hormone, vasopressin, which also increases blood pressure.

The researchers used rats instead of the more commonly studied mice because rats regulate salt and water more like humans. That makes the findings more likely to apply to people, noted lead author Prof. Masha Prager-Khoutorsky.

“This is new evidence that high blood pressure can originate in the brain, opening the door for developing treatments that act on the brain,” says Prof. Prager-Khoutorsky.

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Avoid triggers that raise blood pressure

Giving up salt can be difficult, but an alternative that most people don’t know about is potassium-enriched salt.

It looks the same as traditional salt (sodium chloride), except some of the sodium chloride has been replaced with potassium chloride.

Not only does this salt help reduce your sodium intake, but potassium also works to strengthen your heart muscles.

But in light of this new connection between the brain and inflammation, lowering inflammation should be addressed.

A safe and easy way to do that is by adding omega-3s to your diet by eating fatty fish weekly or supplementing.

An analysis published in the Journal of the American Heart Association has identified the optimal daily amount of omega-3s needed to lower blood pressure.

However, hidden sources of sodium can sabotage all of these efforts. Be sure to check labels, especially on condiments and processed foods.

Finally, another one that most people don’t know: not all hypertension triggers are edible. Other proven hypertension triggers include:

• Loneliness
• Sleep apnea
• Thyroid problems
• Antidepressants
• Holding on to a full bladder
• Cold and migraine medications

I hope the information I’ve given you here has provided some good ammunition against hypertension.

Sources:

Too much salt can hijack your brain — Science Daily

Microglia regulate neuronal activity via structural remodeling of astrocytes — Neuron