How resveratrol helps fight muscle loss and fatigue

If you feel like your muscles get wimpier every year, you can thank a fun little phenomenon called sarcopenia.

Sarcopenia is the loss of muscle mass that occurs naturally with aging. It can start as early as your 30s, but it really kicks into high gear in your 50s and 60s.

Run-of-the-mill sarcopenia stinks. If it gets bad, it can keep you from climbing stairs, carrying groceries, opening a jar of pickles or enjoying physical activities like playing with the grand kids. Basically, it keeps you from living (and enjoying!) your life.

But astronauts have it way worse. Not only do they have age-related sarcopenia to worry about. They have a lack of gravity to contend with.

Sure, floating around in a spaceship sounds fun at first. But your body was built for a world with gravity. In fact, the force of gravity keeps you healthy in a lot of ways…

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For one, it keeps your bones, heart, and muscles strong because it “exercises” these body parts naturally for you. With gravity, every movement you make takes effort, which builds muscle, bone density, and heart health.

After several months without gravity, astronauts’ bones and muscles get weak. That’s why most spaceships nowadays are equipped with a killer exercise room that astronauts visit regularly.

And it’s why looking at the effects of space travel could help provide a sure-fire solution to sarcopenia…

Resveratrol keeps muscles strong even when gravity is weak

A new study from researchers at Harvard shows that the antioxidant resveratrol could help astronauts keep their muscles strong on long missions.

In the study, researchers put rats in either an environment with normal gravity or one that reproduced the gravity of Mars. They added resveratrol to the water supply of half the rats too. And here’s what happened…

The rats in the Mars-like environment lost grip, muscle weight, calf circumference, and slow-twitch muscle fiber. But once they got resveratrol, they regained their grip. In fact, their grip ended up the same as rats who lived in the environment with normal gravity. Rats who received resveratrol also maintained more muscle mass and lost less muscle fiber.

How does resveratrol keep muscles from withering away even in extreme anti-gravity circumstances?

Well, previous rat studies show that resveratrol encourages muscle growth in diabetic rats too. That’s because it improves insulin sensitivity and the amount of glucose absorbed by muscle fibers.

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Put resveratrol to work for your muscles

If resveratrol could potentially keep astronauts’ muscles strong, why can’t it do the same for you?

And by the way, this isn’t the first time resveratrol was shown helpful in the muscle arena. There was a study in 2016 that found resveratrol had big benefits for monkey muscles too…and monkeys are a lot more like humans than rats. In this study, resveratrol made monkey muscles more resistant to fatigue.

Ready to give resveratrol a try?

You’ll find it in a lot of delicious foods and beverages, including peanuts, grapes, red wine, cranberries and blueberries.

There’s also no shortage of resveratrol supplements on the market right now. But if you decide to go the supplement route, make sure to buy trans-resveratrol rather than the cheaper (and less effective) cis-resveratrol. Trans-resveratrol is better absorbed by your body, so it’s worth the extra cost.

Editor’s note: Are you feeling unusually tired? You may think this is normal aging, but the problem could be your master hormone. When it’s not working, your risk of age-related diseases skyrockets. To reset what many call “the trigger for all disease” and live better, longer, click here to discover The Insulin Factor: How to Repair Your Body’s Master Controller and Conquer Chronic Disease!


  1. An antioxidant in red wine might power astronauts on Mars, study says — CNN
  2. A Moderate Daily Dose of Resveratrol Mitigates Muscle Deconditioning in a Martian Gravity AnalogFrontiers in Physiology
  3. How to Fight Sarcopenia (Muscle Loss Due to Aging) — Healthline
  4. Clinical definition of sarcopeniaClinical Cases in Mineral and Bone Metabolism
  5. Resveratrol — Oregon State University
Jenny Smiechowski

By Jenny Smiechowski

Jenny Smiechowski is a Chicago-based freelance writer who specializes in health, nutrition and the environment. Her work has appeared in online and print publications like Chicagoland Gardening magazine, Organic Lifestyle Magazine, BetterLife Magazine,, and