Strengthen your disease defense with alpha lipoic acid

When you first start going to the gym or get back into an exercise program, it’s a big effort. It may even feel like it’s putting more stress on your body than it’s worth.

But after a few weeks of sticking with your new program, that stress is paying off — your body starts feeling stronger and healthier.

There is one nutrient that works in the same way, gently stressing your body to strengthen your defenses — it’s called lipoic acid, also known as alpha-lipoic acid or a-lipoic acid.

Now lipoic acid hasn’t been a big headliner, but that may be about to change. In fact, it may be one of the most important antioxidants discovered…

And this latest discovery may make it a star…

That’s because this little-known nutrient may help slow down the progression of multiple sclerosis (MS). In a pilot study carried out at Oregon Health & Science University School of Medicine in Portland, researchers found that taking a high dose of lipoic acid every day for two years reduced whole-brain atrophy, a marker of MS progression, by 68 percent compared with a placebo.

But that’s not all…

Lipoic acid triggers a whole range of reactions to strengthen your body’s defenses against toxins and cell-damaging free radicals that can make you ripe for disease. And these reactions promote a whole range of health benefits for you…

Ward off chronic disease. Lipoic acid is a potent antioxidant compound that’s found in every cell of your body. The main job of antioxidants is to fight free radicals — unstable rebel cells that cause damage to healthy cells, organs and tissues in your body. This is known as oxidative stress. The more free radicals you have, the higher your risk of developing conditions of all kinds.

Related: 12 symptoms of a free-radical attack.

Lipoic acid is a particularly unique antioxidant as it’s both water and fat-soluble; unlike vitamin C, which is a water-soluble antioxidant; or vitamin E, which is a fat-soluble antioxidant. Better yet, lipoic acid regenerates both vitamin C and E to enhance their antioxidant abilities.

Decrease inflammation. As you age, your body is more prone to developing low-grade inflammation throughout your cells. This is a normal process throughout life as your body fights off outside stimulus from viruses and bacteria, environmental toxins, food toxins, and other factors. But as your body ages, it becomes less resilient and the inflammation abomination can cause disease. Lipoic acid can help keep this inflammation in check.

Weight loss. The results from a clinical trial conducted by the Linus Pauling Institute and the Oregon Health & Science University found that lipoic acid promotes weight loss in women. It has several effects on metabolism including lowering inflammation and oxidative stress, preventing weight gain, speeding up fat metabolism, and lowering cholesterol levels.

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For brain function and stroke prevention. Though there is no conclusive evidence at this stage, researchers suggest lipoic acid may protect brain and nerve tissue, and therefore, prevent stroke and dementia. They are currently investigating its potential because lipoic acid has the unique ability to cross the blood-brain barrier, which many drugs simply can’t do.

Beat diabetic neuropathy. Diabetic neuropathy is an irritating condition caused by nerve damage, the symptoms of which are pain, burning, itching, tingling, and numbness in the arms and legs. It is an extremely serious condition because when there is numbness, ulcers and injuries can occur that can even lead to limb amputations.

Clinical trials indicate that lipoic acid is very effective for the treatment of diabetic neuropathy and another type of neuropathy called, autonomic neuropathy, which affects nerves connected to organs. In Germany, they are using lipoic acid intravenously with great success. But taking a supplement of around 800 mg per day has been shown to reduce symptoms.

Supports liver health. A potent antioxidant, alpha-lipoic acid helps keep fats from accumulating in the liver. Plus, because it’s both fat- and water-soluble, so it can help eliminate free radicals from a fatty liver or a lean liver.

Boost your master antioxidant. Glutathione is the number one antioxidant your body needs to stay healthy and strong. The good news is your body produces glutathione naturally. The bad news is your body probably isn’t producing enough, and when you take it orally it can get destroyed in your gut. But lipoic acid regenerates glutathione!

Foods and supplements. Great dietary sources of lipoic acid include red meat, organ meats (such as liver), broccoli and spinach and brewer’s yeast. For supplements, a general daily dose of 200 to 400 mg is recommended. While for diabetes support or neuropathy the recommended dose is 800 mg per day in divided doses.

Editor’s note: Are you feeling unusually tired? You may think this is normal aging, but the problem could be your master hormone. When it’s not working, your risk of age-related diseases skyrockets. To reset what many call “the trigger for all disease” and live better, longer, click here to discover The Insulin Factor: How to Repair Your Body’s Master Controller and Conquer Chronic Disease!


  1. OREGON STATE UNIVERSITY RESEARCH NEWSLETTER — (2016). Research Newsletter: Fall-Winter 2016. Retrieved 5 June, 2017, from
  2. Oregon Health & Science University. (2017, June 30). Multiple sclerosis: Patients may benefit from over-the-counter therapy: Results will be tested in large-scale clinical trial. — ScienceDaily. Retrieved August 1, 2017
  3. Alpha-lipoic acid — (2017). University of Maryland Medical Center. Retrieved 5 June, 2017
  4. Keith D, et al. Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age. — Biochem Biophys Res Commun. 2014;450(1):324-9.
Jedha Dening

By Jedha Dening

Jedha Dening is a qualified nutritionist (MNutr), researcher, author, freelance writer, and founder of type 2 diabetic nutrition site Diabetes Meal Plans. Her masters thesis on nutrition and inflammation was published and then presented at a national scientific conference. She has millions of words published in the health industry across various print and online publications. Having been in the field for over 15 years, she’s incredibly passionate about delving into the latest research to share the myths and truths surrounding nutrition and health. She believes when armed with the right knowledge, we’re empowered to make informed choices that can truly make a difference.