Alcohol’s hidden partner in the attack on your liver

It’s common knowledge that drinking alcohol can damage the liver, a risk that increases the more a person consumes and the longer they do it.

Now, there are some organs we can continue on without. But the liver is not one of them.

The liver performs hundreds of vital functions, including regulating blood sugar and controlling blood clotting, metabolizing nutrients, and, of course, removing toxins and waste from the bloodstream.

We know that alcohol’s harm to the liver is a direct punch. However, new research has revealed that it’s actually a one-two punch…

What I mean is that, while alcohol is directly attacking the liver, it’s also opening the door to invaders that also play an active role in wreaking havoc on the liver.

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Alcohol lets bacteria into the liver

Let’s start with a primer on what alcohol does to the liver…

• Alcohol harms the liver by triggering inflammation and the buildup of fat, kickstarting fatty liver disease (not to be confused with NAFLD or MAFLD).
• The chemical acetaldehyde, which is produced when the liver metabolizes alcohol, accelerates this harmful process.
• Continued drinking can lead to alcoholic hepatitis, characterized by inflamed and damaged liver cells.
• The most severe stage, irreversible cirrhosis, involves the formation of scar tissue that disrupts liver function and can end in liver failure. 

However, a study at UC San Diego has uncovered a previously unobserved series of events that causes even more damage to the liver…  

When scientists examined human liver biopsies, they found that chronic alcohol use impaired the production of a cellular signaling protein in the small intestine known as mAChR4.

When levels of this protein are lower, it interferes with the formation of cells known as goblet cell-associated antigen passages, or GAPs. These GAPs play a key role in teaching the immune system to respond to microbes that escape the gut.

Without this layer of protection, gut bacteria escape and enter vital organs, including the liver, where they compound the damage already being done by alcohol.

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Added protection for your liver

So when it comes to the liver, the best thing to do it avoid alcohol. But the researchers know that advice is not always easy for everyone.

They hope that by developing drugs that boost levels of mACHR, it may be possible to reverse the series of events that do so much harm to the liver and afford some level of protection.

But ultimately, alcohol is a toxin that directly damages the cells responsible for the tight junctures in the lining of the gut. Alcohol-induced inflammation makes the damage to the lining worse — increasing permeability.

Together, that creates a condition known as leaky gut, which allows bacteria of all sorts to not only reach the liver but also other organs.

The U.S. Dietary Guidelines for Americans suggest limiting alcohol to one drink per day for women and up to two drinks per day for men.

But it’s important to note that even low amounts are still associated with serious health risks, and for some individuals, especially those over 65, the recommended limit should be even lower. 

Sources:

Vicious Cycle Revealed: How Alcohol Helps Gut Bacteria Attack Your Liver — Science Alert

Alcohol Opens the Floodgates for Bad Bacteria — UC San Diego