3-year study proves lipids keeps Alzheimer’s at bay

More than 5 million Americans live with Alzheimer’s disease, including one in every 10 people over the age of 65.

By 2025, the number of people aged 65 and older with Alzheimer’s disease is expected to climb to 7.1 million people, a 27 percent increase from the 5.6 million age 65 and older in 2019.

Of the 10 leading causes of death in the United States, including cancer, heart disease and diabetes, Alzheimer’s is the only disease where existing treatments don’t really help.

But a group of European scientists has been busy trying to change that.

For the past three years, they have been working on a way that nutrition could help slow the progress of Alzheimer’s, prevent dementia, and add quality years to the lives of those with the disease.

The LipiDiDiet Study

For three years, a group of 46 scientists from several European countries conducted the LipiDiDiet study, to test the outcome of a nutritional intervention they believed might slow the progress of Alzheimer’s disease.

In this trial, 311 patients with prodromal Alzheimer’s (also referred to as mild cognitive impairment, or MCI) were given either 125ml of a multi-nutrient drink, or a placebo drink, once a day.

After three years, a neuropsychological test battery measured a 60 percent reduction in cognitive decline, and a 76 percent reduction in memory decline in those who drank the multi-nutrient drink product containing:

  • Docosahexaenoic acid (DHA)
  • Eicosapentaenoic acid (EPA)
  • Uridine monophosphate
  • Choline
  • Vitamins B12, B6, C, E,
  • Folic acid
  • Phospholipids
  • Selenium

Looking more closely at the results, the researchers found that those who had better cognitive performance when the trial started benefited more from the nutritional drink. In other words, the earlier in the course of the disease the nutritional intervention began, the better the results.

Also, brain shrinkage, a hallmark of Alzheimer’s, showed improvement as well. The rates of shrinkage of the hippocampus (the part of the brain involved in short-term memory) were 33 percent less than in the control group, and shrinkage of the whole brain was 20 percent less.

Overall, patients who were given the multi-nutrient drink suffered between 40 and 70 percent less cognitive impairment than those who received the placebo.

The role of lipids in the LipiDiDiet and Alzheimer’s disease

Based on previous observations that lipids change the risk for dementia, the European LipiDiDiet project addresses the impact of nutritional lipids on neuronal and cognitive performance in aging, Alzheimer’s disease and vascular dementia.

So, what are lipids? Lipids are fats, oils, fatty acids, phospholipids and cholesterol. Healthy oils, like olive oil and fish oil, are lipids that have been shown to improve health.

You’ll notice if you look back up at the list of nutrients in the special dietary drink, the first two are DHA and EPA which are omega-3 fatty acids — or lipids — with a reputation for lowering Alzheimer’s risk. That was no accident…

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The connection between Alzheimer’s and lipids goes back over one hundred years when Alois Alzheimer first described what he saw in the brains of his patients: abnormal protein deposits and altered lipid (fat) composition.

That relationship between lipid imbalance and Alzheimer’s was confirmed decades later. We now know that the strongest genetic risk factor for the disease is linked to apolipoprotein E, the major lipid transporter in the central nervous system.

Also, lipids seem to block the formation of the amyloid-β precursor protein, a large membrane protein that, in its normal state, is part of the process of repairing and growing neurons.

When it is altered, though, this is the substance that turns into β-amyloid plaques, which destroy nerve cells and result in the loss of cognition and memory experienced with Alzheimer’s disease.

What to eat to keep your brain healthy

Research is ongoing into the role that lipids play in the progression, and the prevention, of Alzheimer’s disease.

But you can start to adjust your diet NOW, to support your brain’s health and possibly prevent the deterioration that signals the beginning of Alzheimer’s.

The M.I.N.D. diet is a hybrid of the Mediterranean and DASH (Dietary Approaches to Stop Hypertension) diets. Research has shown that it can turn back your brain’s clock almost eight years in terms of cognitive function.

To follow the M.I.N.D. diet, here’s what you should be eating every day:

  • At least three servings of whole grains
  • A green leafy vegetable and one other vegetable
  • A glass of wine
  • A snack of nuts

Fatty fish, full of healthy lipids, should be eaten at least once a week.

The M.I.N.D. diet is also about what you shouldn’t eat:

  • Limit butter to less than 1 1/2 teaspoons a day (try olive oil instead)
  • Eat less than five servings a week of sweets and pastries
  • Limit whole fat cheese and fried or fast food to one serving (or less) per week

Editor’s note: Scientists discovered that glial cells in your brain actually make cholesterol to help your neurons create connections with one another. Your ability to think, form memories and learn — and yes, ALL of your mental functions — are dependent on this process happening smoothly. However, statin drugs harm your glial cells and hinder cholesterol production. To learn more about the statin danger to your brain, click here!

Sources:

LipiDiDiet study finds possible nutrition intervention for early Alzheimer’s — Integrative Practitioner

LipiDiDiet finds broad and sustainable effects of nutrient intervention in early Alzheimer’s disease: Data published in Alzheimer’s & Dementia, the journal of the Alzheimer’s Association — lipididiet.eu

E.U. funded research consortium “LipiDiDiet” finds a way to impact Alzheimer’s Disease before it’s too late: data published in The Lancet Neurology — lipididiet.eu

Alzheimer’s statistics — alzheimer’s.net

The LipiDiDiet trial: what does it add to the current evidence for Fortasyn Connect in early Alzheimer’s disease? — Clinical Interventions in Aging

Lipids are major players in Alzheimer’s disease — Atlas of Science

Joyce Hollman

By Joyce Hollman

Joyce Hollman is a writer based in Kennebunk, Maine, specializing in the medical/healthcare and natural/alternative health space. Health challenges of her own led Joyce on a journey to discover ways to feel better through organic living, utilizing natural health strategies. Now, practicing yoga and meditation, and working towards living in a chemical-free home, her experiences make her the perfect conduit to help others live and feel better naturally.