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Breakthrough: Scientists cause aging cells to self-destruct
Anyone over the age of 50 can tell you that getting older isn’t for the faint of heart.
And I know I’m preaching to the choir, right?
As we age, more aches and pains creep in. Health conditions you’d hoped to avoid begin to pile up. And day-to-day life can feel like a chore.
Now however, an anti-aging breakthrough, thanks to researchers at the Ulsan National Institute of Science and Technology, may lead the way to a new therapy that could actually remove aging cells from the body before they do damage and leave behind only their normal, much more youthful counterparts…
Stopping senescent from kicking off aging
Scientists specifically discovered a way to target what’s known as senescent cells — malfunctioning cells that have begun to break down and just don’t work properly anymore.
When this happens, those old cells begin to churn out proteins that damage other cells around them, kicking off inflammation throughout the body and leading to ailments associated with age.
This process even prevents the replication of stem cells — the cells your body uses to regenerate tissue.
This makes it easy to see why scientists were determined to find a way to rid the body of senescent cells. And the way they went about it is truly cutting-edge…
The researchers designed organic molecules that selectively target receptors overexpressed in the membranes of aging cells. The scientists were able to use these molecules to bind to the mitochondrial membrane of those aging cells, disrupt the membranes and cause the cells to hit the self-destruct button.
“The selective removal of aging cells by targeting the mitochondria and inducing dysfunction has been successfully demonstrated in our experiments,” said lead researcher, Professor Ja Hyoung Ryu. “This approach represents a new paradigm for treating age-related diseases.”
Powerful support for mitochondrial health
So it looks like scientists may soon be able to just remove senescent cells so that we can all age in a healthier way.
Of course, as with all new discoveries, the timeline for exactly when this new therapy will be widely available is hard to nail down.
The good news is that there are ways to support the mechanisms in your body tied to healthier aging, including your mitochondria — instead of just leaving it to chance — using some of the most studied nutrients in the field of aging, including:
- PQQ – Known as the ‘longevity nutrient’, PQQ lowers the risk of age-related disease by improving the function of the mitochondria.
- CoQ10 – Without adequate CoQ10, mitochondria can’t function as they should, and aging accelerates. Research has shown CoQ10 is capable of reviving ailing mitochondria to restore lost function and slow aging. Be aware this is the nutrient statins can lower.
- Resveratrol – Found in the skin of grapes and dark chocolate, resveratrol helps rejuvenate senescent cells, turning back the clock so they behave like youthful cells again.
- Grape seed extract – A polyphenol in grape seeds known as procyanidin C1, or PCC1, has been shown to significantly extend both the healthspan and lifespan of old mice by promoting the death of senescent cells.
- Fisetin – This compound found in fruits like strawberries and apples is a senotherapeutic agent. This means fisetin is capable of specifically targeting only the senescent cells in the damaged tissue to help rein in the damage and slow aging.
So why wait?
Make it harder for those senescent cells to steal your youth and vitality!
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Sources:
Selective removal of aging cells opens new possibilities for treating age-related diseases – EurekAlert!