How this sneaky protein triggers leaky gut syndrome

You could be living with leaky gut right now and not even know it.

In fact, a leaky gut lining could be behind your uncomfortable and even dangerous health issues and yet it could go completely ignored by your doctor.

Sadly, the incidence of undiagnosed celiac disease — an autoimmune condition that damages your gut lining and allows all of the bad stuff from your intestines to leak out — has skyrocketed in the United States over the past 50 years.

Luckily, researchers are now shining a light on just exactly how leaks form in the gut lining, which can provide hope for treatment that works.

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Gas, stomach upset, loose bowels, stomach cramps, headache and fatigue. These are all symptoms of a problem more common than you may think: Gluten intolerance. It’s often linked to autoimmune issues. Instead of the body digesting the protein, it treats gluten as an… MORE⟩⟩

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The gluten connection to leaky gut

As you may already know, if a person has leaky gut syndrome or celiac disease, gluten is not their friend.

Here’s the issue…

Whether you’re enjoying a hearty sandwich, scarfing down a yummy doughnut or having a pancake breakfast, the gluten in the food you eat must be broken down into proteins by an enzyme known as tissue transglutaminase (tTG).

In people without leaky gut or celiac, these proteins are absorbed.

However, in those unlucky enough to have a real problem with gluten, things don’t work as they’re supposed to.

And that’s where the new research comes in…

Scientists from Bielefeld University found that because your body cannot completely break down gluten proteins if you have celiac disease, large gluten fragments, or peptides, can form in your gut.

This happens because a form of the tTG enzyme called tissue transglutaminase 2 (tTG2) modifies gluten proteins, forming structures or oligomers that then build up in the gut lining.

Once there, these large molecules, which the scientists are calling 33-mer deamidated gliadin peptide (DGP) act as a key, opening the tightly closed junctures of the gut lining and leading to leaky gut syndrome.

What happens when your gut leaks?

According to the study, this is a dangerous prospect since, “If 33-merDGP oligomers are formed, they may damage the epithelial cell network, allowing gluten peptides, bacteria, and other toxins to pass massively into the bloodstream, leading to inflammation and, in celiac disease, autoimmunity.”

Just a few of the problems you can experience include:

• Fatigue
• Diarrhea
• Bloating and gas
• Abdominal pain
• Nausea and vomiting
• Constipation
• Headaches
• Joint pain
• Itchy, blistery skin
• Elevated liver enzymes

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In addition, a leaky gut can set off a cycle of weight gain, since endotoxins that escape the gut and enter the bloodstream interfere with the normal functioning of fat cells. Specifically, these toxins stop the browning process that turns bad white fat into calorie-burning beige fat.

Fighting back against leaky gut

Avoiding gluten is the best answer, but doing so is not easy, unless on the strictest of diets. Even ordering gluten-free at restaurants is a big gamble.

The good news is that you can help strengthen and support the health of your gut to reduce your symptoms and your risks.

My colleague, Virginia Tims-Lawson, has put together a list of five must-have supplements to repair a leaky gut.

It’s a list that includes probiotics, which you may get even more of a boost from, by choosing a supplement that’s spore-based.

Finally, be sure and check out this list of five sinister foods to avoid, along with five foods that can offer help leaky gut syndrome.

Sources:

Celiac disease: New findings on the effects of gluten — ScienceDaily

Celiac Disease — Mayo Clinic

Increased Prevalence and Mortality in Undiagnosed Celiac Disease — Gastroenterology